Rules worth keeping
Know the onset of every agent you give. Benzodiazepines work in minutes. Hydroxyzine in fifteen to sixty. Propranolol within the hour. Prazosin over days to weeks. Buspirone takes two to four weeks and is therefore worthless as a PRN — say so out loud, or the person will abandon it in week one. SSRIs and SNRIs take four to six weeks, and eight to twelve for obsessive-compulsive disorder.
Start low and go slow in anxious patients. A full starting dose commonly produces early jitteriness and a genuine worsening of anxiety in the first one to two weeks. A person who is not warned will stop the drug and conclude that medication makes them worse. All antidepressants carry a boxed warning for increased suicidal ideation and behaviour under twenty-five — monitor closely in the first weeks and after every dose change.
Taper, never stop. Abrupt benzodiazepine discontinuation after regular use produces tremor, diaphoresis, autonomic instability, delirium and seizures, and can be fatal. SSRI and SNRI discontinuation syndrome — flu-like symptoms, dizziness, electric-shock sensations, insomnia, irritability — is worst with short-half-life agents such as paroxetine and venlafaxine.
And mind the language. A person asking about their benzodiazepine dose is asking a question. Describe the behaviour, assess the need, and write what you observed — “asked three times today about the timing of her lorazepam and reported that the night dose was late” — rather than a label that ends the thinking of everyone who reads the chart after you.