Genetics · Module 2 · Extensions of Mendel and gene interaction

Extending Mendel Lab

Build a two-gene pathway and watch its F2 grow; run a complementation plate; solve randomized majors-level problems with worked solutions; match ratios and terms; and read real data from dogs, peas, mutant screens and families. Nothing here is graded.

Part 1: Pathway Bench

Enzyme (protein)Missing enzyme (recessive aa or bb)Inhibitor blocks a step Observed shareExpected share (dashed)
Cross totals and chi-square test
MeasureValue
Phenotype classes: observed and expected
PhenotypeGenotypesObservedExpected

Simplifications: genes A and B are on different chromosomes and assort independently; recessive a and b alleles make no enzyme (or no inhibitor); one working copy is enough for each step (except in the additive model, where doses add); every zygote survives; each offspring is drawn by chance from the parents' gametes. The live identification compares the F2 counts with all seven ratios and picks the closest by chi-square (p = 0.05).